Craniofacial surgery is a surgical branch regarding study and treatment of any kind of disease affecting the face. Peculiar to this surgery is that any surgical procedure has non only functional but even esthetical implications such important for all patients’ life. Anatomical and functional complexity of the face and skull makes this area extremely hazardous for any skilled surgeon or fellows in training. Computer-based surgery simulation represents a rapidly emerging and increasingly important area that combines information technology and real time systems for the common purpose of improving health care. It allows the surgeon to operate on a virtual representation of the patient head and to predict the outcome of the real intervention. Several virtual interventions can be executed and evaluated before to proceed to the real surgery.